DNASTAR NovaFold was evaluated by recreating the CASP10 competition, in which participants attempted to predict the structures for a given set of target sequences whose structures were previously unknown. In this benchmark test, NovaFold created predictions for these same target sequences which were then evaluated and scored based on the same metrics used the CASP10 experiment.
Template Modeling Score (TM-score): A normalized measure of similarity between superimposed protein structures that weighs close atom pairs between structures greater than more distant atom pairs. The range varies from 0 to 1, with a higher score indicating a better structural match.
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