Protean - New Features in v8.1

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Protein Structure Prediction and Annotation

Protean Structure Prediction and Annotation

Protean helps you predict and display patterns, secondary structural characteristics and physicochemical properties of protein sequences via its comprehensive suite of protein analysis tools. Protean's simple, elegant graphical user interface can also help you locate antigenic determinants and predict protease digestion patterns. When you find interesting structures, you can utilize the integrated BLAST tool* to search NCBI's databases for related sequences using all or part of your polypeptide as the query. Protean also provides you with the tools to easily annotate and export your findings as reports, pictures or tables.

New Features found in Lasergene v8.1 include:

  • The ability to predict the presence of post-translational sumoylated sites to assist in the study of a wide range of cellular activities
  • Improved export to GenVision for higher quality graphic images.

 

Protean Features

    Protean Images and Displays

  • Display a larger number of Features.
  • Simplified export to GenVision.
  • Increased sorting capability to better customize your analysis.
  • Updated Prosite database.
  • Implement protein profile pattern searches.
  • Ability to customize screen to match your project needs.
    Sequence Entry
  • Import data from many popular file formats
  • Read sequences and features from other Lasergene project files
  • Download sequences directly from NCBI* using accession numbers, BLAST or text searches
  • Edit template sequence and share newly created features through integration with SeqBuilder and other Lasergene applications
    Structure Analysis Methods
  • Choose from any of four methods for recognizing alpha helix, beta sheet, turns and coil structures
  • Predict antigenicity using any of four unique methods
  • Estimate surface probability using the Emini method
  • Predict flexibility using the Karplus-Schultz method
  • Evaluate hydropathy using any of three different methods
  • Predict amphiphilicity using Eisenberg's method
  • Estimate charge density
    Locating patterns and related sequences
  • Locate known sites using Prosite pattern searching
  • Predict Proteolytic digestion sites
  • Simulate electrophoretic separation of proteolytic fragments
  • Submit any selected feature, segment, or all of your sequence as a BLAST query*
  • Investigate related sequences using keywords with the integrated Entrez search tool*
    Graphical Displays
  • Juxtapose or superimpose related analysis methods or displays
  • View your project at base level and at full overview magnification simultaneously
  • Display numerical data as graphs or boxes indicating values above a threshold
  • Choose line colors, fill patterns, and fill colors for all display objects
  • Display features in a variety of shapes and name individual segments
  • Produce tabular summaries
  • Utilize specialized chemical and space-filling fonts
  • Produce secondary structure models

* Requires Internet Connection

» Printable PDF overview for Protean

 

Screenshot

Predict protease-induced fragments via simulated PAGE



Screenshot

View secondary structures such as helical wheels