zRPKM normalization:“Krumm et al., 2012”:https://www.dnastar.com/manuals/seqman-ngen/15.3/en/topic/research-references) is available for the CNV workflow and is calculated as follows:

zRPKM = (RPKMexon, sample – Medianexon) / StdDevexon

This is the optimal normalization method for CNV projects with at least three groups/projects. Otherwise, we recommend using the RPK-CN normalization method.

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