DNASTAR NovaFold is protein structure prediction software that is based on I-TASSER, the award-winning software package developed by Professor Yang Zhang's laboratory at the University of Michigan. NovaFold utilizes the I-TASSER algorithms developed by Prof. Zhang that combine threading and ab initio folding technologies to build accurate, full 3D atomic models of proteins with previously unknown structures.



NovaFold can be accessed in several ways: on the Cloud through NovaCloud Services, on the Cloud as an add-on to Protean 3D, or on a local server at your organization. For more information on NovaFold Local, please check out the Nova Applications User Guide, the NovaFold Local technical requirements, or contact us.



PDF icon White Paper: Accuracy of NovaFold Protein Folding Predictions


PDF icon Lasergene Structural Biology Suite Overview

“I recently had an opportunity to try NovaFold for several protein structure predictions. I was impressed by how well the predicted models fit my expectation. Visualization of the structures in Protean 3D is also beautiful and easy to work with. My ability to evaluate and modify the structures as necessary is made very easy in your software.”

– Samir Naimov DSc, University of Plovdiv "Paisii Hilendarski"

Features & Highlights


Predict 3D Structure Based on Protein Sequence

  • Use NovaFold’s hybrid method of protein structure prediction to yield highly accurate models of any size molecule. This approach first identifies structural fragments by comparing them to a template library, then incorporates both these and the unmatched fragments into the final structure
  • Predict ligand binding sites and protein function
  • Assess NovaFold prediction quality through support of structure and sequence alignment


High Performance and Flexibility

  • Access NovaFold through Protean 3D's menus and panels, integrating structure prediction with your existing protein analysis work
  • Save money on hardware upgrades by harnessing the power of Cloud computing for structure prediction
  • Select a term license which allows you to run NovaFold for a predefined period of time, or choose to pay per prediction
  • Approximate prediction runtimes are available on our benchmarks page