NovaDock explores protein flexibility when docking, resulting in more accurate protein-protein interaction predictions.
Modeling a protein-protein docking interaction is generally more difficult than predicting the structure of an individual protein, and because of its complex nature, accuracy can be a concern. NovaDock offers the ability to predict protein-protein docking interactions for any two binding partners utilizing SwarmDock, one of the top algorithms validated in the CAPRI blind docking experiment. Utilizing the SwarmDock algorithm, NovaDock explores protein flexibility when docking, resulting in more accurate predictions. Simply provide your ligand and receptor PDB or structure files, proposing specific residue contacts between the binding partners if desired. NovaDock will then predict the three-dimensional structure of the macromolecular complex and provide energy score, cluster size, and number of ligand contacts for each model for analysis.