Create highly accurate protein models, unattainable through standard modeling methodologies.
Predicting the 3D structure of a protein from its amino acid sequence is so important because having a protein structure model provides a greater level of understanding of how a protein works, which can allow us to create hypotheses about how to affect it, control it, or modify it. Many tools for protein structure prediction rely solely on homology modeling, which only works well for proteins that have a high degree of sequence similarity to protein sequences in the Protein Data Bank. The benefit of NovaFold is that it utilizes the award-winning I-TASSER protein structure prediction algorithm, combining threading and ab initio folding technologies, which finds more distant relationships than sequence similarity alone, improving the quality and accuracy of the predicted structure. Use NovaFold to create highly accurate, full 3D atomic models of proteins, unattainable through standard modeling methodologies.