Use Lasergene Protein’s protein design software to perform essential protein stability predictions in minutes.
Protein stability prediction is essential for optimizing protein functional studies, but many standard approaches to improving solubility and expression are often ineffective due to degradation or thermodynamic instability. Our protein design software, part of Lasergene Protein, includes protein mutation stability prediction tools that use a deterministic protein design algorithm find the global minimum energy conformation (GMEC). This allows you to make changes at the residue-level on a protein structure and predict whether these changes are likely to be stabilizing or destabilizing compared to the original structure, a beneficial process for PCR site-directed mutagenesis.
Our protein stability prediction tools also make it easy to search for amino acid positions that are important for protein stability by performing computational alanine scanning or serine scanning to detect hot-spots, residues whose variants destabilize the structure. Select from multiple energy potentials for protein stability calculations, including DFIRE-A and a selection of AMBER potentials.
Use Lasergene Protein’s advanced protein design software to perform accurate protein stability predictions in minutes!
