Variant Analysis Software

SNP to Structure Analysis

DNASTAR Lasergene

DNASTAR Lasergene allows you to combine genomic sequencing and variant level data with structure files from the PDB to model point mutations on the protein structure and assess the effect on protein stability. By combining structural bioinformatics with sequencing technologies, this integrated workflow can guide genomic and molecular biology researchers to create structure-based hypotheses and to investigate possibilities not evident by sequences alone. Our software enables you to:

  • Quickly and easily assemble large data sets from all major next-gen technologies on a desktop computer—check out our benchmarks
  • Perform variant analysis for a variety of project types, including whole genome sequencing, exome and targeted sequencing, gene panels, and RNA-Seq
  • Utilize DNASTAR's new human genome template package, which bundles together data from dbSNP and GERP, as well as Ensembl and the Protein Data Bank.
  • Perform large-scale comparisons of variants across individuals and groups of individuals, determine the level of disruption to each gene caused by the variants present, and locate variants with published structure files
  • Model variants of interest in Protean 3D and view the mutated side chain along the backbone
  • Use DFIRE energy calculations to predict whether the mutation is stabilizing or destabilizing to the protein structure
  • Apply solvent-accessible surfaces to further explore potential impact of mutation on protein stability and function
  • Analyze secondary structure characteristics to interrogate mutation's effect on protein flexibility, amphiphilicity, charge density, hydropathy, and more

 Note: The use of this workflow requires assembly with the Homo sapiens - Ensembl w/PDB genome template package.

For a more in-depth look at the SNP to Structure Workflow, please view our poster:

 Software for In Silico 3-D Protein Structure Predictions from DNA Sequence Variation Data

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