If you are working with templated human assemblies, Lasergene’s “SNP to Structure” workflow lets you combine genomic sequencing and variant level data with structure files from the RCSB Protein Data Bank (PDB) to model point mutations on the protein structure and assess the effect on protein stability. By combining structural bioinformatics with sequencing technologies, this integrated workflow can guide genomic and molecular biology researchers to create structure-based hypotheses and to investigate possibilities not evident by sequences alone.
This workflow requires that you be licensed to use several Lasergene applications: SeqMan NGen, SeqMan Pro and Protean 3D (all required), and ArrayStar (optional).
Only Part D of the workflow involves Protean 3D. However, all parts of the workflow are described below.
Need more help with this?