Lasergene 15 is coming soon!


In the next several weeks, we will be announcing the release of Lasergene 15, a major upgrade to the DNASTAR Lasergene Suite. This release is very exciting for us, in part because it includes a complete overhaul of SeqBuilder, the foundation of our Molecular Biology Suite. In fact, the revamp was major enough that we felt it needed a new name — SeqBuilder Pro. Enjoy all of the functionality you know and love, but with a more intuitive and streamlined design.


This release also includes significant enhancements to our Structural Biology and Genomics suites. Check out the sections below and watch our sneak peek video to learn more!

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PDF icon Lasergene Version Comparison Guide



New SeqBuilder Pro Application


For our Lasergene Molecular Biology Suite customers, this is huge. SeqBuilder has morphed into a much more intuitive and streamlined application we're calling SeqBuilder Pro. Don't worry, all of the functionality you know and love is still there: sequence map creation, primer design, virtual cloning, and all the rest, but it's easier and more intuitive to use! The most obvious change is a new state-of-the-art look and feel that is consistent with many other Lasergene applications. Now you can easily navigate between synchronized views with a click of a button, and rearrange views and toolbars by simply dragging and dropping them where you want them to be.


We've also improved upon many of the functions you rely on, such as creating sequence maps. New zoom-level sliders and an auto-placement for large groups of restriction enzymes makes creating the perfect map a breeze. You can also now quickly search and select enyzmes with our new responsive search feature. For our long-time users who still use our legacy EditSeq application, we've added a new "compact view" that mimics the EditSeq layout. Views that list items like features and primers can now be collapsed, expanded, and sorted to easily find and edit what you're looking for. Speaking of features, SeqBuilder Pro supports multiple selection, so if for example, you want to find all the features of a certain type and change the style, it's just a couple of clicks away.

Mutation Modeling in Protean 3D


For Structural Biology Suite users, Protean 3D now has the ability to mutate one or more single residues, and calculate whether these changes are likely to be destabilizing compared to the original structure. Simply select the residue of interest and enter the desired amino acid substitution to view the modeling results including a change in energy value based on the DFIRE calculation, indicating whether the mutation is destabilizing or non-destabilizing. Once applied to your document, the mutant molecule is displayed in addition to the original structure and can be hidden and displayed as desired.

Reduced False Positives During SNP Calling


If you are familiar with Lasergene Genomics Suite, you'll know that for years, we've ranked #1 in accuracy for NGS alignments and variant calling. In Lasergene 15, we're offering an option to further fine-tune our accurate variant detection method by adding a new enhanced read mapping option for whole genome alignments. This option gives users a choice to either use the default variant detection parameters, which offers the fastest alignment, or dramatically reduce the detection of false positives identified during SNP calling, by using the new option. Your objective for each project may be different, so the choice is yours.

Additional Updates in Lasergene 15


  • Auto-naming of primers in SeqBuilder Pro
  • Ability to directly import SnapGene files into SeqBuilder Pro
  • Support for aligning subsequences in MegAlign Pro
  • Import of gapped FASTA alignments in MegAlign Pro
  • Export of editable images in PowerPoint and PDF in Protean 3D
  • Full feature editing in Protean 3D
  • Integration of NovaCloud applications into Protean 3D
  • Improved handling of GFF files in SeqMan NGen

Lasergene 14.1 Released Applications



The most current released version of all Lasergene applications for Windows is 14.1.2, included in the DNASTAR Lasergene 14.1b installer.

The most current released version of all Lasergene applications for Macintosh is 14.1.0, included in the DNASTAR Lasergene 14.1a installer.



For current customers, all of our upgrades are included as part of your service plan. If you have a current (non-expired) service plan, you may login to access the latest version of your software.



If you are not a current customer, feel free to try out Lasergene 14.1 by downloading a fully-functional free trial, or request a quote to purchase.