NovaLocal Technical Requirements
NovaLocal Technical Requirements
NovaLocal enables protein structure prediction and modeling workflows to run locally through Docker Desktop integration in Protean 3D. System requirements vary depending on the workflows being used, with advanced structure prediction applications such as Boltz-2 requiring additional compute and GPU resources.
Review the requirements below to determine the recommended configuration for your environment.
General NovaLocal Requirements
| Component | Requirement |
|---|---|
| Operating System | Windows 11 or supported Mac systems |
| Docker Platform | Current version of Docker Desktop |
| Processor | Multi-core Intel or AMD processor |
| RAM | 16 GB minimum |
| Storage | 100 GB available disk space |
Additional Requirements for Boltz
Structure Prediction
| Component | Recommended |
|---|---|
| GPU | NVIDIA RTX 4090 (24 GB VRAM minimum) |
| RAM | 64 GB |
| Storage | 1 TB available disk space1 |
| mmseqs Access | Required |
1 Approximately 1 TB of storage is recommended when configuring a local mmseqs database server.
Compatibility Notes
- Boltz workflows currently require NVIDIA GPU acceleration.
- Mac systems are supported for select NovaLocal workflows, but GPU-accelerated Boltz predictions are not currently supported on macOS.
- Boltz workflows require access to an mmseqs alignment server, which may be hosted by DNASTAR, ColabFold, or configured locally.
Supported Methods in NovaLocal:
- AlphaFold-Multimer – Multi-chain protein structure prediction
- Boltz – Biomolecular complex structure prediction
- NovaFold Antibody – Antibody and antibody fragment modeling
- NovaDock – Protein-protein docking