LASERGENE 18.1 RELEASE NOTES
Lasergene 18.1 introduces powerful new capabilities across genomics, molecular biology, and protein analysis, along with usability and performance improvements throughout the suite. This release delivers expanded variant calling with new GATK-powered workflows, multi-sample Sanger assembly in SeqMan Ultra, next-generation protein interaction modeling with the Boltz-2 model, advanced isoform profiling, and new support for local database BLAST in SeqBuilder Pro. Together, these enhancements give researchers greater accuracy, speed, and confidence in every stage of analysis.
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Variant Analysis
Get deeper insights into germline and somatic variation with industry-standard tools and new visualization capabilities in Lasergene Genomics.
- Leverage GATK’s HaplotypeCaller for high-quality germline variant discovery.
- Analyze paired tumor/normal or tumor-only datasets with GATK’s Mutect2 somatic variant caller.
- Enhance tumor-only analyses with new gnomAD VCF filtering.
- Compare multiple paired tumor–normal experiments in GenVision Pro with a new Analysis view that lets you visualize tumor and normal alignments side by side.
Long-Read & RNA Analysis
Unlock the power of long-read sequencing and RNA-Seq in Lasergene Genomics to capture isoforms, transcripts, and structural complexity.
- Assemble long-read RNA-Seq data to enable comprehensive mRNA analysis.
- Perform Iso-Seq alignment and visualization for improved transcript discovery.
- Explore mRNA isoforms in a new dedicated alignment track in GenVision Pro.
Genome Visualization & Variant Exploration
See, interpret, and share your results faster with new multi-sample support and enhanced visualization and filtering capabilities in GenVision Pro.
- Analyze multiple samples in one project with new support for up to 50 human exomes and expanded data track visualizations for large-scale variant analysis.
- Robust variant filtering lets you limit the Variants table and Analysis view tracks to include only the variants of most interest to you.
- Filter displayed variants by chromosome and refine results further using any of 22 pre-computed filters, including Mutect2-specific values such as GERMQ, MMQ, or POPAF, to help distinguish somatic from germline variants.
- Understand structural variations better with enhanced displays for split reads.
- Export variants to VCF format for downstream use.
Sanger Assembly
SeqMan Ultra now supports multi-sample Sanger assembly, giving you the flexibility to choose between a classic SeqMan workflow and a genomics-driven approach.
- Assemble multi-sample Sanger data using the SeqMan algorithm in SeqMan Ultra, with a user interface similar to classic SeqMan Pro.
- Alternatively, run multi-sample Sanger assemblies with SeqMan NGen to align Sanger data to human chromosomes and access advanced variant analysis tools, such as the VAD, available to genomics customers.
Protein Structure & Interactions
Protean 3D now includes ultra-fast, accurate modeling of protein interactions, expanding the range of analyses available for your structural biology research.
- Model protein interactions with DNA, RNA, and small molecules using the new Boltz-2 model, an open-source analogue of AlphaFold 3 that delivers fast, accurate, and cost-effective results. Boltz-2 can accurately predict entire protein complexes, including multiple protein subunits, DNA binding sites, and small molecule ligands.
Database & Search
Manage and search your data more efficiently, so you can spend less time setting up and more time analyzing.
- Create and organize sequence databases in SeqBuilder Pro to enable rapid local BLAST searches, joining functionality already available in GenVision Pro, Protean 3D, SeqMan Ultra, and MegAlign Pro.
- Perform text searches on local databases, now supported across all applications with local BLAST functionality.
- Build and manage custom databases for plasmid auto-annotation directly in SeqBuilder Pro.
Workflow Access & Utilities
Navigate, launch, and validate workflows more easily with the enhanced DNASTAR Navigator.
- Find the right application faster with an improved, user-friendly layout.
- View workflows in your choice of eight languages.
- Download data directly from the Short Read Archive (~10 million datasets) and automatically convert to FASTQ format.
- Check sequence quality quickly using the integrated FastQC tool.
- Compare and quantify agreement between variant calls with the GATK VCF concordance tool.
Additional Enhancements
Additional enhancements that streamline your experience and boost performance throughout the Lasergene suite.
- Remove outliers in multiple-sequence alignments using your choice of distance metrics, length, or name in MegAlign Pro.
- View variants sooner after adding experiments in GenVision Pro, with the variant database now computed at assembly.
- Load and navigate data tracks faster, even when zoomed out in GenVision Pro.
- Receive warnings when importing VCFs that don’t match the reference sequence in GenVision Pro.
- Access your work more quickly with the new Welcome screen in SeqBuilder Pro.
- Run DNASTAR Java-based applications natively on Apple Silicon for seamless performance on modern hardware.
Recent Webinars
Practical Workflows for Sanger Sequence Projects
Streamlined Variant Analysis with new GATK Tools in Lasergene
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