The Transmembrane – von Heijne track predicts hydropathy based on the interaction between the signal sequence and membrane, using the approach of von Heijne et al., 1981. The Transmembrane – von Heijne method is similar to Goldman-Engleman-Steitz, another Protean 3D method that uses the Hopp-Woods algorithm. The von Heijne method uses estimates of the standard free energy transfer of residues that transition from a random coil conformation in water to a helical conformation in a non-polar environment.

To apply this track to the sequence:

In the Tracks panel, expand Transmembrane and check the box next to von Heijne. The track will now be visible in the Analysis view

To edit track options:

Select the track in the Tracks panel. Open the Track Options section, which appears as follows:

  • Residues to Average – number of residues to be averaged when constructing each point in the plot. The default is 17.

Click if you wish to return to the default settings.

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